ABSTRACT
Abstract Venous refilling time (VRT) can diagnose the presence of venous diseases in lower limbs. In order to calculate VRT it is necessary to determine the End of the Emptying Maneuvers (EEM). First Derivative Method (FDM) can be employed for automatic detection of the EEM, but its sensitivity to artifacts and noise can degrade its performance. In contrast, studies report that Area Triangulation Method (ATM) evinces effectiveness in biosignals point finding. This work compares the exactness of ATM and FDM for recognition of the EEM. The annotations made by 3 trained human observers on 37 photoplethysmography records were used as a reference. Bland-Altman graphics supported the analysis of agreement among human observers and methods, which was complemented with Analysis of variance and Multiple Comparisons statistical tests. Results showed that ATM is more accurate than FDM for automatic detection of the EEM, with statistically significant differences (p-value < 0.01).